Persistent anxiety and in-hospital complications after acute coronary syndrome
Objectives: To investigate the effects of pre-event persistent anxiety on in-hospital complications and length of stay in patients who experienced acute coronary syndrome.
Methods: This was a prospective study with patients seeking treatment for acute coronary syndrome events. Anxiety was measured two times before the event in 600 patients with pre-existing coronary heart disease. Patients were followed for two years or until they developed an acute coronary syndrome event. One hundred and twenty patients developed acute coronary syndrome events (rate 20%). Complications and length of stay were abstracted from medical records.
Results: Persistently non-anxious patients have lower anxiety scores at three months follow up than baseline (mean [SD], 6.1 [0.24] vs 3.9[0.95], P< .01). Patients with persistent anxiety had significantly higher complication rates than non-anxious patients (mean [SD], 0.71 [0.12] vs 0.15[0.11], P < .05). In a multiple logistic regression, persistent anxiety was an independent predictor of complications. Patients who were persistently anxious were at five times higher risk for developing complications (OR=5.0, 95 % CI: 1.27-38.8, P< .05)
Conclusion: Anxiety measured up to two years prior to an acute coronary syndrome event was predictive of in-hospital complications. Clinicians caring for patients with coronary heart disease need to be as equally aware of the importance of assessing and treating persistent anxiety as clinicians caring for patients hospitalized for an acute coronary syndrome.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).